当前位置 : 首页 >> 科研动态 >> 正文
科研动态

2017年健康学院教师发表论文摘要

作者:   发布时间:2018-04-12  浏览次数:



欧阳艳琼

论文摘要:

Family-Centered Breastfeeding Education to Promote Primiparas’ Exclusive Breastfeeding in China

Journal of Human Lactation2017,publishing online(通讯作者)


Abstract

Background: Few breastfeeding education programs focus on primiparas and the importance of family members on exclusive breastfeeding in China.

Research aim: This study aimed to explore the influence of a family-centered breastfeeding education program in promoting exclusive breastfeeding up to 6 months postpartum and to improve women’s attitude and knowledge, family members’ knowledge, and family support.

Methods: This was a two-group quasi-experimental design with multiple comparisons. Participants (N = 59) were randomized to either the intervention (n = 29) or the control (n = 30) group. The intervention group received two prenatal

breastfeeding education lectures that included important family members, three home visits, eight telephone calls, text or video/audio support, and quality online resources during lactation. The control group received in-hospital care and follow-up by community nurses after discharge.

Results: Compared with the control group, the intervention group was more likely to exclusively breastfeed in the first 6 months, odds ratio = 0.44, 95% confidence interval [0.20, 0.98]. The mean knowledge level of the intervention group improved more across time (p < .05) and was higher than the control group (p < .05). Perceived family support within the intervention group was significantly higher than the control group from 1 to 6 months (p < .05).

Conclusion: The breastfeeding education program is an effective strategy to promote exclusive breastfeeding in China.

Keywords: breastfeeding, breastfeeding promotion, breastfeeding rates, breastfeeding support, exclusive breastfeeding, lactation education


A meta-analysis   of pelvic floor muscle training for the treatment of urinary incontinence

Intentional Journal  of Gynecology & Obstetrics 2017; 138: 250(通讯作者)

Abstract

Background: Symptoms associated with urinary incontinence (UI) frequently affect quality of life.

Objectives: To assess the effects of pelvic floor muscle training (PFMT) among women with UI .

Search strategy: The Cochrane Library, PubMed, and Web of Science databases were searched using relevant terms for all English-language

studies published up to August 15, 2016.

Selection criteria: Studies that evaluated the effects of PFMT on UI symptoms, PFM function, and quality of life were included.

Data collection and analysis: Data were screened and collected by two independent investigators. Pooled effect sizes and 95% confidence intervals (CIs) were calculated.

Main results: Twelve studies were included, involving 763 patients. Use of PFMT

increased PFM strength when measured by digital palpation and the Muscle Strength Oxford Scale (standardized mean difference [SMD] 1.18, 95% CI 0.56–1.80). The PFM pressure was increased by PFMT when measured using a perineometer (SMD 0.40, 95% CI 0.07–0.73). Finally, PFMT improved quality of life (SMD 1.67, 95% CI 0.41–2.94).

Conclusions: Regular use of PFMT provided symptom relief and improved quality of life among women with UI.

Keywords: Meta-analysis; Pelvic floor muscle training; Pelvic floor muscles; Quality of life; Stress urinary incontinence; Urgency urinary incontinence


Attitudes of Chinese Adults to Breastfeeding in Public: A Web-Based Survey

Breastfeeding Medicine, 2017,12(5):316(通讯作者)

Abstract

Objective: To explore Chinese adults’ perceptions and attitudes toward breastfeeding in public places.

Materials and Methods: This was a web-based survey including 10 items on breastfeeding participants (N = 2,021) who were recruited by convenience sampling.

Results: Almost 95% believed that public places should have lactation rooms, 86% thought it was acceptable for mothers to breastfeed in this location, and 65% of respondents agreed that it was acceptable for mothers to breastfeed in public. Though 47% believed that viewing women breastfeeding in public was embarrassing, more than 80% felt that breastfeeding in public was appropriate and decent and did not violate social morality. More

than 90% of respondents approved of policies supporting breastfeeding in public. Women, married people, those who had children, had some knowledge about breastfeeding, or had the experience of viewing women breastfeeding in public were more likely to hold positive perceptions and attitudes toward breastfeeding in public places.

Conclusions: Prior experience and knowledge about breastfeeding have a great influence on people’s perceptions and attitudes toward breastfeeding in public, so education about breastfeeding is very important. Breastfeeding education should not only include the techniques of breastfeeding practices but also include information policies that support breastfeeding in public, including the importance of lactation rooms.

Keywords: public places, breastfeeding, attitude, web-based survey, China


孟宪梅

Factors associated with perceived participation three months after being discharged from a tertiary hospital

Clinical rehabilitation, 2017, 31 (9) :1257-1266(第三作者)

Abstract

Objectives: To describe how first-stroke survivors perceive their participation and the problems with such participation in life and to determine the factors associated with perceived participation at three months after hospital discharge.

Design: A cross-sectional study.

Setting: Patients were recruited from a tertiary hospital in Shanghai, China and they were followed up in their homes.

Subjects: Two hundred and fifty-seven first-stroke survivors discharged for three months participated in this study.

Measures: The Chinese version of the Impact on Participation and Autonomy questionnaire, Barthel Index, Chinese Stroke Scale, Hospital Anxiety and Depression Scale and Social Support Rating Scale.

Results: One hundred thirty-four (52.1%) and 147 (57.2%) participants perceived their participation as poor to very poor in the domains of family role and autonomy outdoors, respectively. Conversely, 208 (80.9%) and 228 (88.7%) participants perceived their participation to be fair to good in the domains of social relations and autonomy indoors, respectively. The ability to perform activities of daily life was the strongest correlate of participation in the domains of autonomy indoors, family role, and autonomy outdoors, whereas anxiety was the strongest correlate of participation in the domain of social relations.

Conclusions: Activities of daily living were significantly associated with perceived participation in almost all domains. In contrast, anxiety was an important factor in predicting participation in the domain of social relations. These findings suggest the need to explore different strategies of promoting participation for each domain.



崔丹

Use of and microbial resistance to antibiotics in China: a path to reducing antimicrobial resistance.

Journal of International Medical Research. 30th Jan, 2017.(第一作者)



蔡春凤

Quality of Life in Patients With Schizophrenia in China: Relationships Among Demographic Characteristics, Psychosocial Variables, and Symptom Severity

J Psychosoc Nurs Ment Health Serv. 2017 Aug 1;55(8):48-54. doi: 10.3928/02793695-20170627-03.(第一作者)

论文摘要:

The aim of the current study was to examine the relationships among demographic characteristics, psychosocial variables, symptom severity, and quality of life (QOL), and the way these variables affect QOL in patients with schizophrenia living in Hubei, China. A convenience sample of 178 individuals with schizophrenia participated. The results suggest that the Schizophrenia Quality of Life Scale was positively and statistically significantly correlated with employment status (r = 0.232, p < 0.01) and monthly household income (r = 0.311, p < 0.01), positively correlated with personal empowerment (r = 0.692; p < 0.001), and negatively correlated with perceived stigma (r = –0.41, p < 0.01) and symptom severity (r = –0.54, p < 0.001). Illness uncertainty was not found to have a relationship with QOL in this sample. Among all variables, personal empowerment (accounting for 22.1% of variance) was the best positive predictor, whereas symptom severity (accounting for 7.6% of variance) was the best negative predictor of QOL in patients with schizophrenia. Implications for future research and practice are discussed.


顾耀华

The Effects of vSIM for Nursing™ as a Teaching Strategy on Fundamentals of Nursing Education in Undergraduates

clinical simulation in nursing2017134):194-197(第一作者)

论文摘要:

Virtual simulation offers various benefits and should be considered in future nurse education. This study aimed to report the effectiveness of vSIM for Nursing as a supplemental teaching strategy on performance of undergraduate students in a Fundamentals of Nursing course. This was a randomized, controlled, posttest design. Twenty-eight undergraduates were randomly assigned to experimental or control groups. In the experimental group, ten virtual cases were additional to regular course procedure. In the control group, students received regular course procedure only. Knowledge test and skill performances were compared between groups. Thirteen students in the experimental group and 14 students in the control group completed the study. Students in the experimental group had significantly higher knowledge scores than students in the control group. Results in this study indicates that the vSIM for Nursing might be an effective supplementary teaching strategy to improve students' knowledge of Fundamentals of Nursing.


胡松波

论文摘要:

Age–Period–Cohort Analysis of Stroke Mortality in China: Data From the Global Burden of Disease Study 2013

Stroke.2017,48,p271-275.(第二作者)

1. In this paper, we define and study some subclasses of multivalent analytic functions of higher order in the unit disc. These classes generalize some classes previously studied. We obtain coefficient inequalities, distortion theorems, extreme points, and integral mean inequalities. We derive some results as special cases.

2. Background and Purpose—Stroke has been the leading cause of death in China. The aim of this study is to assess the long term trends of stroke mortality in China between 1994 and 2013. Methods—The mortality data were obtained from the GBD 2013 and were analyzed with the APC framework. Results—We found that the net drift was ?2.665% per year for men and ?4.064% per year for women, and the local drift values were below 0 in all age groups in both sexes during the period of 1994 to 2013. In the same birth cohort, the risk of death from stroke rose exponentially with age for both sexes after controlling for period deviations. The estimated period and cohort relative risks were found in similar monotonic downward patterns for both sexes, with more quickly decreasing for women than for men during the whole period.

Conclusions—The decreased mortality rates of stroke in China are likely to be related to improvements in medical care and techniques, spectacular economic growth and fast urbanization, and better early life nutrition conditions of Chinese people. Besides, better education and better awareness of stroke-related knowledge in successive generations could also probably play a role.


刘晴

论文摘要:

Protection motivation theory in predicting intention to receive cervical cancer screening in rural Chinese women

Psycho-oncology,2017,27(10),page:1-8(通讯作者)

OBJECTIVE:

Despite the significance of cervical cancer screening, motivating more women to participate remains a challenge in resource-limited settings. In this study, we tested the protection motivation theory (PMT) inpredicting screening intentions.

METHODS:

Participants were women from Wufeng, a typical rural county in China. Participants (n = 3000) with nocervical cancer history were recruited from 10 randomly selected villages. As mediating variables, 6 PMT constructs (Perceived Risk, Fear Arousal, Perceived Severity, Response Efficacy, Response Cost, and Self-Efficacy) were measured using the standardized questionnaire. Structural equation modeling (SEM) method was employed to test PMT-based prediction models.

RESULTS:

Of the total sample, 57.77% believed that regular screening may reduce cervical cancer risk, and 45.26% agreed that women should be screened regularly. Our data fit the PMT model well (GFI = 0.95, AGFI = 0.93, CFI = 0.90, RMSEA = 0.06, SRMR = 0.04, Chi-square/df = 2.47). Knowledge of screening was directly and positively associated with screening intention. Age, annual income, and awareness of and prior experience with screening were significantly associated with screening intention by enhancing cervical cancer risk perception and by reducing response cost (P<0.05 for both).

CONCLUSION:

PMT can be used as guidance to investigate cervical cancer screening intentions among ruralwomen in China with focus on cancer knowledge, some demographic factors, and awareness of and previous experience with screening. These findings, if verified with longitudinal data, can be used for intervention program development.

KEYWORDS:

China; cervical cancer; knowledge; oncology; protect motivation theory (PMT); rural women; structural equation modeling (SEM)


黎浩

Estimating the Direct Medical Economic Burden of Health Care–Associated Infections in Public Tertiary Hospitals in Hubei Province, China

Asia-Pacific Journal of Public Health. 2017;29(5):440-450(第一作者)

论文摘要:

Abstract

This study estimated the attributable direct medical economic burden of health care–associated infections (HAIs) in China. Data were extracted from hospitals’ information systems. Inpatient cases with HAIs and non-HAIs were grouped by the propensity score matching (PSM) method. Attributable hospitalization expenditures and length of hospital stay were measured to estimate the direct medical economic burden of HAIs. STATA 12.0 was used to conduct descriptive analysis, bivariate χ2 test, paired Z test, PSM (r = 0.25σ, nearest neighbor 1:1 matching), and logistic regress analysis. The statistically significant level was set at .05. The HAIs group had statistically significant higher expenditures and longer hospitalization stay than the non-HAIs group during 2013 to 2015 (P < .001). The annual average HAI attributable total expenditure, medicines expenditure, out-of-pocket expenditure, and number of hospitalization days per inpatient were (2015 US$) 6173.02, 2257.98, and 1958.25 and 25 days during 2013 to 2015. The direct medical cost savings was estimated at more than 2015 US$12 billion per year in Chinese tertiary hospitals across the country. The significant attributable direct medical economic burden of HAIs calls for more effective HAI surveillance and better control with appropriate incentives.


Data Envelopment Analysis for Relative Efficiency Measurement of Chinese Hospitals: A Systematic Review

Research in Health Science. 2017;2(2):79-103(通讯作者)

The purpose was to explore the gap between China and the international world in efficiency measurement of hospitals with Data Envelopment Analysis, and to improve the standardization of healthcare efficiency measurement in China. A systematic review was conducted using appropriate search strategies. Studies were included containing DEA approaches regarding general hospital efficiency, published in international literature and in both Chinese and English about Chinese hospitals from January 2004 to October 2014. The results showed that statistical significances were found in indicators such as number of DMUs, percentage of allocative efficiency studies, ratio of studies with multiple years, number of studies with monetary indicators in input and output sets, etc. The statistical insignificance in some indicators such as the number of input and output indicators were also found among China, Europe, USA and others. Some problems were found in current DEA-based hospital efficiency studies in China, such as inappropriate selection of input-output indicators, no bias-correction on efficiency scores, etc. The standardization of DEA methods applied in China’s hospital efficiency research needs to be improved. Chinese researchers should pay more attention to latest international research findings, so as to keep pace with the cutting edge hospital efficiency research.

李得加

MicroRNAs: A novel potential biomarker for diagnosis and therapy in patients with non-small cell lung cancer

作者: Zhou, Qun; Huang, Shao-Xin; Zhang, Feng; .

CELL PROLIFERATION  : 50   : 6     文献号: e12394   出版年: DEC 2017 (通讯作者)

论文摘要

Background: Lung cancer is still one of the most serious causes of cancer-related deaths all over the world. MicroRNAs (miRNAs) are defined as small non-coding RNAs which could play a pivotal role in post-transcriptional regulation of gene expression. Increasing evidence demonstrated dysregulation of miRNA expression associates with the development and progression of NSCLC.

Aims: To emphasize a variety of tissue-specific miRNAs, circulating miRNAs and miRNA-derived exosomes could be used as potential diagnostic and therapeutic biomarkers in NSCLC patients.

Materials & Methods: In the current review, we paid attention to the significant discoveries of preclinical and clinical studies, which performed on tissue-specific miRNA, circulating miRNA and exosomal miRNA. The related studies were obtained through a systematic search of Pubmed, Web of Science, Embase.

Results: A variety of tissue-specific miRNAs and circulating miRNAs with high sensitivity and specificity which could be used as potential diagnostic and therapeutic biomarkers in NSCLC patients. In addition, we emphasize that the miRNA-derived exosomes become novel diagnostic biomarkers potentially in these patients with NSCLC.

Conclusion: MiRNAs have emerged as non-coding RNAs, which have potential to be candidates for the diagnosis and therapy of NSCLC.


Echinocystic acid ameliorates hyperhomocysteinemia-induced vascular endothelial cell injury through regulating NF-kappa B and CYP1A1

作者: Huang, Chuan-Feng; Wang, Wei-Na; Sun, Cheng-Cao; .

EXPERIMENTAL AND THERAPEUTIC MEDICINE  : 14   : 5   : 4174-4180   出版年: NOV 2017 (通讯作者)

The present study investigated the role of echinocystic acid (EA) on the expression of nuclear factor (NF)-kappa B and cytochrome P450 1A1 (CYP1A1), and aortic morphology, in a rat model of hyperhomocysteinemia (Hhcy). A total of 50 Sprague Dawley rats were randomly divided into five groups as follows: Normal control (NC), model control (MC), vitamin control (VC; folic acid 1 mg/kg + vitamin B2 2 mg/kg + vitamin B12 10u g/kg), EA1 (20 mg/kg EA) and EA2 (40 mg/kg EA). Plasma homocysteine (Hcy) levels were determined via high performance liquid chromatography, and the morphology of the aorta was investigated using hematoxylin and eosin staining. Furthermore, aortic mRNA and protein levels of NF-kappa B and CYP1A1 were measured using reverse transcription-quantitative polymerase chain reaction analysis and western blotting, respectively. Plasma Hcy levels, and aortic mRNA and protein levels of NF-kappa B and CYP1A1, were significantly lower in the EA-treated group compared with the MC group (all P<0.05). However, the aortic morphology remained normal, including the endothelial cells of the inner layer, and smooth muscle cells of the media layer and adventitia. In conclusion, the results of the present study indicate that EA has a protective role on vascular endothelial cells in Hhcy through decreasing plasma Hcy, and thus NF-kappa B and CYP1A1 expression.


miR-206/133b Cluster: A Weapon against Lung Cancer?

作者: Pan, Jing-Yu; Sun, Cheng-Cao; Bi, Zhuo-Yue; .

MOLECULAR THERAPY-NUCLEIC ACIDS  : 8 : 442-449 出版年: SEP 15 2017 3 (通讯作者)

Lung cancer is a deadly disease that ends numerous lives around the world. MicroRNAs (miRNAs) are a group of non-coding RNAs involved in a variety of biological processes, such as cell growth, organ development, and tumorigenesis. The miR-206/133b cluster is located on the human chromosome 6p12.2, which is essential for growth and rebuilding of skeletal muscle. The miR-206/133b cluster has been verified to be dysregulated and plays a crucial role in lung cancer. miR-206 and miR-133b participate in lung tumor cell apoptosis, proliferation, migration, invasion, angiogenesis, drug resistance, and cancer treatment. The mechanisms are sophisticated, involving various target genes and molecular pathways, such as MET, EGFR, and the STAT3/HIF-1 alpha/VEGF signal pathway. Hence, in this review, we summarize the role and potential mechanisms of the miR-206/133b cluster in lung cancer.


Targeting XPC/ERK/Snail/E-Cadherin Pathway, miR-346 Facilitates Cell Growth and Metastasis, and Suppresses Cell Apoptosis in Human Non-Small Cell Lung Cancer

作者: Sun, Chengcao; Li, Shu-Jun; Li, De-Jia(通讯作者)

会议: 20th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT) 会议地点: Washington, DC 会议日期: MAY 10-13, 2017
会议赞助商: Amer Soc Gene & Cell Therapy

MOLECULAR THERAPY  : 25   : 5   增刊: 1   : 68-69   会议摘要: 143   出版年: MAY 2017


Targeting XPC/ERK/Snail/E-Cadherin Pathway, miR-346 Facilitates Cell Growth and Metastasis, and Suppresses Cell Apoptosis in Human Non-Small Cell Lung Cancer

作者: Sun, Chengcao; Li, Shu-Jun; Li, De-Jia(通讯作者)

会议: 20th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT) 会议地点: Washington, DC 会议日期: MAY 10-13, 2017
会议赞助商: Amer Soc Gene & Cell Therapy

MOLECULAR THERAPY  : 25   : 5   增刊: 1   : 68-69   会议摘要: 143   出版年: MAY 2017


CDK3 is a major target of miR-150 in cell proliferation and anti-cancer effect

作者: Wang, Liang; Xi, Yongyong; Sun, Chengcao; .

EXPERIMENTAL AND MOLECULAR PATHOLOGY  : 102   : 2   : 181-190   出版年: APR 2017 (通讯作者)

MiR-150, a member of small non-coding RNAs, has been proven to dysregulate in different types of tumor and bear on carcinogenesis and cancer prognosis by regulating the expression of a series of gene including utrophin. Given that utrophin can compensate for dystrophin's absence and be regarded as a promising therapeutic target for Duchenne Muscular Dystrophy (DMD), we further detected the deep role of miR-150 in dystrophic muscle. Using a range of bioinformatic, molecular and cell biology techniques, we declared thatmiR-150 directly targets cyclin-dependent kinase 3 (CDK3) and leads to the regulation of CDK3 gene expression in both muscle-derived and non-muscle cells. The results indicated the expression of miR-150 was upregulated inmdxmuscle and closely related to the lower level of CDK3. Transient transfection of miR-150 into cultured C2C12 cells led to significant decrease in cell proliferation, which is partly mediated via the 3'-UTRs of CDK3 mRNA. Targeting of CDK3 could also play a role, at least in part, in the anti-cancer activity suggested for miR-150 in previous studies. Consistently, the analysis of tumor and matched normal lung tissues indicates that miR-150 downregulation in lung tumors correlates with higher CDK3 levels. In addition, miR-150 transfection experiments with cancer-derived cell lines reveal thatmiR-150-mediated CDK3 suppression directly induces to growth inhibition. Collectively, our results highlight a novel activity for CDK3 inmyoblast cell proliferation and confirm CDK3 as a key target that further enhances the tumor suppressor function proposed for miR-150. (C) 2017 Elsevier Inc. All rights reserved.



miR-134: A Human Cancer Suppressor?

作者: Pan, Jing-Yu; Zhang, Feng; Sun, Cheng-Cao; .

MOLECULAR THERAPY-NUCLEIC ACIDS  : 6   : 140-149   出版年: MAR 17 2017 (通讯作者)

9

NMicroRNAs (miRNAs) are small noncoding RNAs approximately 20-25 nt in length, which play crucial roles through directly binding to corresponding 30 UTR of targeted mRNAs. It has been reported that miRNAs are involved in numerous of diseases, including cancers. Recently, miR-134 has been identified to dysregulate in handles of human cancers, such as lung cancer, glioma, breast cancer, colorectal cancer, and so on. Increasing evidence indicates that miR-134 is essential for human carcinoma and participates in tumor cell proliferation, apoptosis, invasion and metastasis, drug resistance, as well as cancer diagnosis, treatment, and prognosis. Nevertheless, its roles in human cancer are still ambiguous, and its mechanisms are sophisticated as well, referring to a variety of targets and signal pathways, such as STAT5B, KRAS, MAPK/ERK signal pathway, Notch pathway, etc. Herein, we review the crucial roles of miR-134 in scores of human cancers via analyzing latest investigations, which might provide evidence for cancer diagnose, treatment, prognosis, or further investigations.


罗先武

The effectiveness, safety and comfort of StatLock securement for peripherally inserted central catheters: a systematic review and meta-analysis

Nursing & Health Sciences(第一作者)

论文摘要:

The aim of this systematic review and meta-analysis was to evaluate the effectiveness, safety and comfort of Statlock? for securement of peripherally inserted central catheters (PICCs). PubMed, EMBASE, the Cochrane library, China National Knowledge Infrastructure (CNKI), WanFang Database and China Science and Technology Journal Database (VIP) were searched. Randomized controlled trials (RCTs) comparing StatLock? with tape or suture on the performance of securing PICCs were selected. Meta-analysis was performed using Review Manager 5.3 software. Thirteen RCTs involving 1,970 patients were included. Our results showed that StatLock? reduced the incidence of catheter dislodgement and unplanned removal; moreover, patients in the StatLock? group had lower incidence of skin ulceration, phlebitis, CRBSI and cellulitis, and felt more comfortable compared with those in the control group. Current evidence suggests that StatLock? securement device offer advantages over tape and suture in preventing catheter-related complications and improving patient’s comfort. However, as considerable heterogeneity was found among the included studies and the quality of evidence for main outcomes was relatively low, the results should be viewed with caution.


苏键镁

Microcalorimetric study of the effect of manganese on the growth and metabolism in a heterogeneously expressing manganese-dependent superoxide dismutase (Mn-SOD) strain

Journal of Thermal Analysis and Calorimetry, 2017, 130(3): 1407-1416(第一作者)

论文摘要:In bacteria, manganese (Mn) is best understood for its roles in protection against oxidative stress as a cofactor of manganese-dependent superoxide dismutase (Mn-SOD). There are four SOD enzymes, including two distinct Mn-SOD proteins (SodA1 and SodA2), with an approximately 53% amino sequence identity to each other, one Cu/Zn-SOD and one Fe-SOD in Bacillus thuringiensis. The specific activity of heterogeneously expressed SodA1 enzyme in Escherichia coli was 10860 U/mg, which was enhanced with the addition of elevated exogenous Mn(II) levels and reached the highest specific activity (14519 U/mg) at 80 μM Mn(II). However, neither the purified SodA1 enzyme nor the E. coli recombinant strain BL21-SOD could oxidize Mn(II) in vitro and in vivo. The growth of BL21-SOD strain was also increased by 2 mM Mn(II) and its intracellular accumulated Mn(II) level reached 41.5 μM. The obtained power-time curves from microcalorimetric assay demonstrated that Qpeak of BL21-SOD cultivated with 2 mM Mn(II) was significantly increased, which was 3.55-fold and 3.85-fold higher than the parent strain BL21(DE3) and control strain BL21-pET respectively, indicating that the exposure of Mn(II) and accompanying oxidative stress might induce and activate the overproduction of SodA1 to eliminate toxic O2-.


孙承操

论文摘要:

1. The lncRNA PDIA3P interacts with miR-185-5p to modulate oral squamous cell carcinoma progression by targeting cyclin D2.

Mol Ther Nucleic Acids2017 9:100-110(第一作者、通讯作者)

  Long noncoding RNAs (lncRNAs) are emerging as important regulators during tumorigenesis by serving as competing endogenous RNAs (ceRNAs). In this study, the qRT-PCR results indicated that the lncRNA protein disulfide isomerase family A member 3 pseudogene 1 (PDIA3P) was overexpressed in oral squamous cell carcinoma (OSCC) and decreased the survival rate of OSCC patients. CCK-8 and clonal colony formation assays were used to detect the effects of PDIA3P on proliferation. Results revealed that silencing PDIA3P by small interfering RNA (siRNA) inhibited OSCC cell proliferation and repressed tumor growth and reduced the expression of proliferation antigen Ki-67 in vivo. Furthermore, the interaction between PDIA3P and miRNAs was then analyzed by qRT-PCR and luciferase reporter gene assay. We found that PDIA3P negatively regulated miR-185-5p in OSCC cells. Simultaneously, we found that silencing PDIA3P by siRNA suppressed proliferation via miR-185-5p in OSCC cells. Moreover, silencing PDIA3P by siRNA inhibited CCND2 protein (no influence on mRNA levels) expression via miR-185-5p in OSCC cells, and CCND2 facilitated cell proliferation of SCC4 and SCC15 cells induced by sh-PDIA3P#1. Therefore, our study demonstrated that PDIA3P may be a therapeutic target for the treatment of OSCC.

2. miR-134: A Human Cancer Suppressor?

Mol Ther Nucleic Acids2017 6:140-149(通讯作者,共同第一作者)

  MicroRNAs (miRNAs) are small noncoding RNAs approximately 20-25 nt in length, which play crucial roles through directly binding to corresponding 3' UTR of targeted mRNAs. It has been reported that miRNAs are involved in numerous of diseases, including cancers. Recently, miR-134 has been identified to dysregulate in handles of human cancers, such as lung cancer, glioma, breast cancer, colorectal cancer, and so on. Increasing evidence indicates that miR-134 is essential for human carcinoma and participates in tumor cell proliferation, apoptosis, invasion and metastasis, drug resistance, as well as cancer diagnosis, treatment, and prognosis. Nevertheless, its roles in human cancer are still ambiguous, and its mechanisms are sophisticated as well, referring to a variety of targets and signal pathways, such as STAT5B, KRAS, MAPK/ERK signal pathway, Notch pathway, etc. Herein, we review the crucial roles of miR-134 in scores of human cancers via analyzing latest investigations, which might provide evidence for cancer diagnose, treatment, prognosis, or further investigations.

3. miR-206/133b Cluster: A Weapon against Lung Cancer?

Mol Ther Nucleic Acids2017 8:442-449(通讯作者,共同第一作者)

  Lung cancer is a deadly disease that ends numerous lives around the world. MicroRNAs (miRNAs) are a group of non-coding RNAs involved in a variety of biological processes, such as cell growth, organ development, and tumorigenesis. The miR-206/133b cluster is located on the human chromosome 6p12.2, which is essential for growth and rebuilding of skeletal muscle. The miR-206/133b cluster has been verified to be dysregulated and plays a crucial role in lung cancer. miR-206 and miR-133b participate in lung tumor cell apoptosis, proliferation, migration, invasion, angiogenesis, drug resistance, and cancer treatment. The mechanisms are sophisticated, involving various target genes and molecular pathways, such as MET, EGFR, and the STAT3/HIF-1α/VEGF signal pathway. Hence, in this review, we summarize the role and potential mechanisms of the miR-206/133b cluster in lung cancer.

4. MicroRNAs: A novel potential biomarker for diagnosis and therapy in patients with non-small cell lung cancer

Cell Prolif201750(6)e12394(通讯作者)

Background: Lung cancer is still one of the most serious causes of cancer-related deaths all over the world. MicroRNAs (miRNAs) are defined as small non-coding RNAs which could play a pivotal role in post-transcriptional regulation of gene expression. Increasing evidence demonstrated dysregulation of miRNA expression associates with the development and progression of NSCLC.

Aims: To emphasize a variety of tissue-specific miRNAs, circulating miRNAs and miRNA-derived exosomes could be used as potential diagnostic and therapeutic biomarkers in NSCLC patients.

Materials & Methods: In the current review, we paid attention to the significant discoveries of preclinical and clinical studies, which performed on tissue-specific miRNA, circulating miRNA and exosomal miRNA. The related studies were obtained through a systematic search of Pubmed, Web of Science, Embase.

Results: A variety of tissue-specific miRNAs and circulating miRNAs with high sensitivity and specificity which could be used as potential diagnostic and therapeutic biomarkers in NSCLC patients. In addition, we emphasize that the miRNA-derived exosomes become novel diagnostic biomarkers potentially in these patients with NSCLC.

Conclusion: MiRNAs have emerged as non-coding RNAs, which have potential to be candidates for the diagnosis and therapy of NSCLC.

5. MiRNA-based therapeutic strategy in lung cancer

Curr Pharm Des2017doi: 10.2174/1381612823666170725141954.published online)(通讯作者)

Lung cancer is one of the most common malignant tumors in the world. Although advanced therapies have been applied for the treatment of lung cancer, the prolongation of overall survival is limited due to treatment resistance. MicroRNAs (miRNAs) are a class of small non-coding, endogenous RNA molecules (about 19-23 nucleotides in length), which could regulate numerous human genes and play key roles in a variety of diseases. MiRNAs are dysregulated in lung cancer and participate in tumor initiation, development and drug resistance. Recent studies showed a new therapeutic strategy for cancer therapy based on miRNAs. In this review, we briefly summarize one classic pathway of miRNAs in lung cancer, and discuss a new miRNA-based therapeutic strategy to manage lung cancer.


谭晓东

论文摘要:

1. Rapid Risk Assessment Report for Schistosomiasis Epidemic in Jianli County Caused by the Sunk "Oriental Star" Cruise Ship

Disaster Med Public Health Prep2017,15:1-7(第二作者、通讯作者)

BACKGROUND: At 9:28 pm on June 1, 2015, the cruise ship "Oriental Star" sank into Yangtze River in Jianli County, with 422 people killed. When the accident occurred, the Chinese government took immediate action and dispatched more than 9000 rescuers. The risk for outbreak of schistosomiasis was increased because of the shipwreck. Obviously it is critical to carry out risk assessment as soon as possible. METHODS: By means of the Delphi method, the situation was analyzed so that the government could fathom the severity of the accident. Then, through matrix and sigma-plotting (3-dimensional graphics) methods, related authorities performed risk assessment after site investigation. RESULTS: The latest news reported that more than 9000 people were involved in the rescue. The affected river was analyzed and mapped using SigmaPlot software, according to which the possibility, harmfulness, and controllability of the accident were determined to be medium (6), medium (6), and poor (7), respectively. CONCLUSION: The site of the accident where the cruise ship sank and rescue operations were carried out is a schistosomiasis epidemic area with high mortality and morbidity. The chance of an outbreak of the schistosomiasis epidemic in Jianli County is quite high. To protect people in this county from the epidemic, relevant logistic services should be arranged and all remains should be cleared up carefully.

2. New strategies to improve the health of Chinese people by 2030

Aust J Prim Health. 2017 Sep;23(4):307-308(第一作者)

In October 2016, the leadership team of the Communist Party of China (CPC) adopted a plan aiming to build a healthy China over the next 15 years. The strategic tasks, mainly focused on promoting healthy lifestyles, optimising health services, improving health protection, building a healthy environment and  developing the health industry, were proposed to deal with the health problems faced by China. According to the plan, China's health plan is likely to undergo a major change.

3.

4. Prehypertension and its optimal indicator among adults in Hubei Province, Central China, 2013-2015.

Clin Exp Hypertens. 2017;39(6):532-538(第二作者、通讯作者)

BACKGROUND: Hypertension accounts for 7% of the annual global disease burden, despite great efforts to counter this trend. Thus, interventions targeted at prehypertension might lead to a breakthrough for hypertension prevention. This  study focused on the prevalence of prehypertension among adults in Central China and the best indicator of prehypertension, which would provide the basis for future interventions. METHODS: This cross-sectional study was conducted using  multistage stratified random sampling in seven counties in Hubei Province. Data from 30,634 survey respondents were analyzed using logistic regression and receiver operating characteristic (ROC) curve statistical tests, for the prevalence of prehypertension and the predictive ability of body mass index(BMI), waist-to-height ratio (WHtR), and waist circumference (WC) for prehypertension. RESULTS: The prevalence of prehypertension in adults was 42.2%. The following factors contributed to the risk of prehypertension: male sex, elder age, divorce/separation, drinking, heavy labor intensity, and high BMI (p <0.05). Being a farmer and exercise exhibited positive associations with prehypertension (p < 0.05). Compared with BMI and WHtR, WC had a higher predictive value for prehypertension (area under ROC curve, AUC = 0.630, 95% confidence interval: 0.623-0.637, p < 0.0001), especially for men. The optimal cutoffs of WC for prehypertension were 79.95 cm in men and 76.85 cm in women. CONCLUSIONS: The prehypertension rate in adults was high in Central China. Significant factors related to hypertension were identified. More interventions targeting individuals with WC above the cutoff level are needed for timely awareness of prehypertension and early prevention of hypertension.

5. Establishment of first engineering specifications for environmental modification to eliminate schistosomiasis epidemic foci in urban areas

Acta Trop. 2017 Aug;172:132-138(第二作者、通讯作者)

Snail control is a key link in schistosomiasis control, but no unified methods for eliminating snails have been produced to date. This study was conducted to explore an engineering method for eliminating Oncomelania hupensis applicable to urban areas. The engineering specifications were established using the Delphi method. An engineering project based on these specifications was conducted in Hankou marshland to eliminate snails, including the transformation of the beach surface and ditches. Molluscicide was used as a supplement. The snail control effect was evaluated by field investigation. The engineering results fulfilled the requirements of the design. The snail density decreased to 0/0.11m(2), and the snail area dropped to 0m(2) after the project. There was a statistically significant difference in the number of frames with snails before and after the project (P<0.05). Snails were completely eliminated through one year of continuous monitoring, and no new snails were found after a flood disaster. This  study demonstrates that engineering specifications for environmental modification were successfully established. Environmental modification, mainly through beach and ditch remediation, can completely change the environment of Oncomelania breeding. This method of environmental modification combined with mollusciciding was highly effective at eliminating snails.

6. Assessment of hospital length of stay and direct costs of type 2 diabetes in Hubei Province, China.

BMC Health Serv Res. 2017 Mar 14;17(1):199(第三作者、通讯作者)

BACKGROUND: The incidence of type 2 diabetes is increasing, creating a huge burden for China's social healthcare system. This study aimed to evaluate hospital length of stay (LOS) based on admission characteristics and direct costs correlated with various types of complications for type 2 diabetic inpatients in Hubei Province, China. METHODS: A total of 1528 inpatients diagnosed with type 2 diabetes discharged between April 1, 2013, and March 31, 2014, were included in this study. Information regarding patients' admission and hospitalization were obtained from the hospital information system. The relationship between admission characteristics and LOS, distribution of total costs, and types of complications were described and analysed. RESULTS: (1) The mean LOS was 11.65 days (median: 10 days). Multiple linear regression analysis demonstrated that inpatients with New Cooperative Medical Scheme (NCMS), aged 80 and above, had longer LOS than the reference group, and inpatients with chronic or acute + chronic complications had shorter LOS than those without. (2) Mean total costs per patient were US$159.72 +/- 130.83 (median: US$135.33), US$240.60 +/- 166.58 (median: US$192.09), and US$247.98 +/- 166.22 (median: US$200.99) for inpatients with no complications, chronic complications, and acute + chronic complications, respectively. Total and    individual costs were significantly less for patients without complications than  for those with the two types of complications (p < 0.001). (3) Mean total costs  per paient were US$225.40 +/- 115.32 (median: US$200.34), US$221.25 +/- 177.64 (median: US$170.05), and US$275.18 +/- 193.14 (median: US$217.91) for inpatients with microvascular complications, macrovascular complications, and microvascular + macrovascular complications, respectively. Total costs were significantly higher for patients with microvascular + macrovascular complications than for those with other types of chronic complications (p < 0.001). (4) Drugs were the greatest expense for patients, and the least expensive treatment was nursing care. CONCLUSIONS: Medical insurance status, age, and type of complication may help to predict LOS for patients with type 2 diabetes in Hubei Province, China. The total and individual costs for patients with complications were higher than for those without, and hospitalization expenses posed a heavy burden. Efforts should be made to reduce the financial impact on patients by integrating the medical insurance system of urban and rural areas, and by reducing the risk of complications, especially microvascular complications.

7. Trends of Esophageal Cancer Mortality in Rural China from 1989 to 2013: An Age-Period-Cohort Analysis.

Int J Environ Res Public Health. 2017 Feb 23;14(3).(通讯作者)

Background: Esophageal cancer is one of the most common cancers in rural China. The aim of this study was to describe the time trends of esophageal cancer mortality in rural China and to better elucidate the causes of these trends. Methods: The mortality data were obtained from the World Health Organization Mortality Database and the China Health Statistical Yearbook Database. The mortality data were analyzed with age-period-cohort (APC) analysis. Results: Our study indicates that the Age-Standardized Mortality Rates (ASMRs) in rural China generally decreased from 1989 to 2003, and thereafter increased until the year 2008 in both sexes. After 2008, the ASMRs decreased again. The results of APC analysis suggest that the general decrease in esophageal cancer mortality in rural China from 1989 to 2003 might be caused by the downtrend of the cohort effects and period effects, while the general increase in mortality from 2004 to 2008 might be caused by the uptrend of the period effects. The decrease in mortality after 2008 may be relevant to the Four Trillion RMB Investment Plan launched by the Chinese Government. Conclusions: The declining cohort effects were probably related to the improvement of socioeconomic status in childhood and the decreasing consumptions of alcohol drinking and smoking, while the trends of the period effects were relevant to the changes in the dietary pattern. Our findings may help predict future changes in esophageal cancer mortality.

8. VIA/VILI is more suitable for cervical cancer prevention in Chinese poverty-stricken region: a health economic evaluation.

BMC Public Health. 2017 Jan 25;17(1):118(第二作者、通讯作者)

BACKGROUND: Screening is the main preventive method for cervical cancer in developing countries, but each type of screening has advantages and disadvantages. To investigate the most suitable method for low-income areas in China, we conducted a health economic analysis comparing three methods: visual inspection with acetic acid and Lugol's iodine (VIA/VILI), ThinPrep cytology test (TCT), and human papillomavirus (HPV) test. METHODS: We recruited 3086 women aged 35-65 years using cluster random sampling. Each participant was randomly assigned to one of three cervical cancer screening groups: VIA/VILI, TCT, or HPV test. In order to calculate the number of disability-adjusted life years (DALYs) averted by each screening method, we used Markov models to estimate the natural development of cervical cancer over a 15-year period to estimate the age of onset and duration of each disease stage. The cost-effectiveness ratios (CERs), net present values (NPVs), benefit-cost ratios (BCRs), and cost-utility ratios (CURs) were used as outcomes in the health economic analysis. RESULTS:  The positive detection rate in the VIA/VILI group was 1.39%, which was 4.6 and 2.0 times higher than the rates in the TCT and HPV test groups, respectively. The positive predictive value of VIA/VILI (10.53%) was highest while the rate of referral for colposcopy was lowest for those in the HPV?+?TCT group (0.60%). VIA/VILI performed the best in terms of health economic evaluation results, as the cost of per positive case detected was 8467.9 RMB, which was 24503.0 RMB lower than that for TCT and 5755.9 RMB lower than that for the HPV test. In addition, the NPV and BCR values were 258011.5 RMB and 3.18 (the highest), and the CUR was 2341.8 RMB (the lowest). The TCT performed the worst, since its NPV was <0 and the BCR was <1, indicative of being poorly cost-beneficial. CONCLUSIONS: With the best economic evaluation results and requiring minimum medical resources, VIA/VILI is recommended for cervical cancer screening in poverty-stricken areas in China with high incidence of cervical cancer and lack of medical resources.

9. Immunisation status and determinants of left-behind children aged 12-72 months in central China

Epidemiol Infect. 2017 Jul;145(9):1763-1772.(第二作者、通讯作者)

Many parents move from rural China to urban areas in search of job opportunities, and leave their children behind to be raised by relatives. We aimed to assess the immunisation coverage, including the 1:3:3:3:1 vaccine series (one dose of Bacilli Chalmette-Guérin vaccine; three doses of live attenuated oral poliomyelitis vaccine; three doses of diphtheria, tetanus and pertussis combined; three doses of hepatitis B vaccine; and one dose of measles-containing vaccine), in children aged 12-72 months and identify the determinants of immunisation uptake among left-behind children in Hubei Province, Central China, in 2014. In this cross-sectional study using the World Health Organization's cluster sampling technique, we surveyed 1368 children from 44 villages in 11 districts of Hubei Province. The socio-demographic and vaccination status data were collected by interviewing primary caregivers using a semi-structured questionnaire and reviewing the immunisation cards of the children. Univariate and multivariate analyses were used to identify the determinants of complete vaccination and age-appropriate vaccination. For each dose of the five vaccines, the vaccination coverage in the left-behind and non-left-behind children was >90%; however, the age-appropriate vaccination coverage for each vaccine was lower in left-behind than in non-left-behind children. For the five vaccines, the fully vaccinated rate of left-behind children were lower than those of non-left-behind children (89·1%, 92·7%; P = 0·013) and age-appropriate immunisation rate of left-behind children were lower than those of non-left-behind children (65·7%, 79·9%; P < 0·001). After controlling for potential confounders, we found that the parenting pattern, annual household income and attitude of the primary caregiver towards vaccination significantly influenced the vaccination status of children. Moreover, we noted a relatively high prevalence of delayed vaccination among left-behind children. Hence, we believe that the age-appropriate immunisation coverage rate among left-behind children in rural areas should be further improved by delivering and sustaining primary care services.


汪春红

论文摘要:

1.The Relationship of Children's Intelligence Quotient and Blood Lead and Zinc Levels: a Meta-analysis and System Review.

Biol Trace Elem Res. 2017 doi: 10.1007/s12011-017-1093-0.(通讯作者)

The purpose of this study was to analyze the existing studies and to investigate the relationship between children's full-scale intelligence quotient (FIQ), verbal IQ (VIQ), and performance IQ (PIQ) and their blood lead (Pb) and zinc (Zn) levels. All documents in Chinese and English were collected from the PubMed, Web of Science, and Chinese National Knowledge Infrastructure (CNKI) databases from inception date to December 30, 2016. RevMan software (version 5.2) was used for the meta-analysis and Stata software (version 12.0) for the meta-regression and sensitivity analyses. A total of 32 eligible literatures was included in the study. Seven prevalence studies showed that the blood Pb level was negatively correlated with children's IQ. The results of the meta-analysis from 22 case-control studies indicate a significant difference between FIQ and PIQ with blood Pb levels, detailed as the FIQ score with a weighted mean difference (WMD)?=?-6.60 (95% CI: -9.01, -4.20), P?<?0.001; PIQ WMD?=?-8.85 (95% CI: -12.651, -5.05), P?<?0.001; but VIQ WMD?=?-3.32 (95% CI: -6.98, 0.33), P?>?0.05. Three studies on the blood Zn concentrations were with a FIQ WMD?=?7.88 (95% CI: -0.07, 15.83), VIQ WMD?=?7.73 (95% CI: -7.40, 22.86), and PIQ WMD?=?6.69 (95% CI: -7.13, 20.51), all P?>?0.05. The results indicate that Pb is harmful to children's intelligence development, especially in PIQ. Zn is beneficial to intelligence, although more studies are needed.

2.Different exposure levels of fine particulate matter and preterm birth: a meta-analysis based on cohort studies

Environ Sci Pollut Res Int. 2017 Aug;24(22):17976-17984.(通讯作者)

The previous studies estimated the association between PM2.5?(particulate matter with aerodynamic diameter less than or equal to 2.5?μm) exposure during pregnancy and preterm birth, only considered and highlighted the hazard effects of high levels of air pollutant exposure, and underestimated that low levels of pollutant exposure might also affect pregnancy outcome. We conducted a meta-analysis of 11 cohort studies, a total of more than 1,500,000 subjects. The results of these studies were pooled by exposure levels and study periods. PM2.5?exposure during pregnancy was positively associated with preterm birth (OR?=?1.15, 95% CI?=?1.07-1.23), and during the first trimester of pregnancy, low levels of PM2.5?exposure were also positively associated with preterm birth (OR?=?1.17, 95% CI?=?1.04-1.30). It is important to protect pregnant women from PM2.5?exposures, especially during their first trimester of pregnancy even when the ambient PM2.5?concentration is relatively low. More relevant health policy should be carried out to prevent hazard effect of air pollutants.

3.Heavy Metal Level in Human Semen with Different Fertility: a Meta-Analysis.

Biol Trace Elem Res. 2017 Mar;176(1):27-36(通讯作者)

There are conflicting reports on the heavy metal levels in human semen with different fertilities. The purpose of this analysis is to merge and analyze the differences of heavy metal lead (Pb), cadmium (Cd), zinc (Zn), and copper (Cu) levels in male semen with normal and low fertilities. All documents in both Chinese and English were collected from the PubMed, Web of Science, and Chinese National Knowledge Infrastructure (CNKI) database from inception date to February 19, 2016. We have used RevMan software (version 5.2) for the meta-analysis and Stata software (version 12.0) for the meta-regression and sensitivity analyses. A total of 20 literatures were included in the study. The results of the meta-analysis indicate a significant difference between fertility with three metal ions (Pb, Cd, Zn) while no significant difference with copper, detailed as follows: (i) 10 studies on the lead concentrations with a standardized mean difference (SMD)?=?2.07, 95 %CI (0.97, 3.17), P?<?0.01; (ii) 13 studies on the cadmium concentrations with an SMD?=?0.75, 95 %CI (0.44, 1.07), P?<?0.01; (iii) 8 studies on the concentrations of zinc with an SMD?=?-0.61, 95 %CI (-1.08, -0.14), P?<?0.01; and (iv) 9 studies on the copper concentrations with an SMD?=?0.42, 95 %CI (-0.29, 1.13), P?=?0.247. The results indicate that the men with low fertility have higher semen Pb and Cd levels and lower semen Zn levels; more studies are needed to indicate the association of the semen copper level with fertility

4.Protective Effects of PGC-1α Against Lead-Induced Oxidative Stress and Energy Metabolism Dysfunction in Testis Sertoli Cells

Biol Trace Elem Res. 2017 Feb;175(2):440-448(通讯作者)

The reproductive system is sensitive to lead (Pb) toxicity, which has long been an area of research interest, but the underlying mechanisms remain to be illustrated. Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is pivotal in mitochondrial function. In this study, mouse testis Sertoli cells (TM4 cells), PGC-1α lower-expression (PGC-1α(-)) TM4 cells and PGC-1α overexpression (PGC-1α(+)) TM4 cells were used to explore the protective roles of PGC-1α against lead toxicity on the mouse reproductive system. Lead acetate (PbAc) exposure decreased the expression level of PGC-1α, increased the intracellular level of reactive oxygen species (ROS), and reduced the level of ATP in the three TM4 cell lines. The effects of PbAc on intracellular ATP level and on ROS content were significantly weakened in PGC-1α(+)TM4 cells versus TM4 cells and were significantly amplified in PGC-1α(-)TM4 cells versus TM4 cells. These results suggest that PGC-1α is a protective factor against PbAc-induced oxidative stress and energy metabolism dysfunction in the mouse reproductive system, thereby holding the potential of being developed as a preventive or therapeutic strategy against disorders induced by lead exposure


王素青

论文摘要:

α-klotho: a novel regulator in female reproductive outcomes and hormone-related cancer

International journal of clinical & experimental medicine,2017,10(5):8511-8521

(第三作者)

α-klotho, as an anti-aging protein, has been involved in a wide range of biological functions, especially in calcium, phosphate and vitamin D metabolism. Recent studies suggested that α-klotho plays important roles in female reproductive development, pregnancy, infant health and hormone related cancers. Effects of α-klotho include anti-oxidation, promoter methylation, histone deacetylation and IGF, FGF, Wnt signaling pathways transduction. In this paper, we provide a seminal view on recent advances in understanding the behavior of α-klotho in female productive health, primarily focusing on the gaps in current research that underline insights into its function and mechanism, and suggest a new avenue for systematic future research.


The impact of an increased progesterone-to-follicle number ratio on live delivery rates in women with normal ovarian reserve.

International journal of Gynecology Obstetrics20171391:84-89(第三作者)

To explore the relationship between progesterone-follicle number (P/F) ratio and live delivery rate in patients with normal ovarian reserve undergoing cleavage-stage embryo transfer with a long gonadotropin-releasing hormone agonist cycle. Methods: The present retrospective study included data from patients younger than 38 years with normal ovarian reserve who were undergoing in vitro fertilization/intracytoplasmic sperm injection and embryo transfer at Zhongnan Hospital, Wuhan University, China, between January 1, 2009 and December 31, 2015. Patients underwent cleavage-stage fresh embryo transfer with a long gonadotropin-releasing hormone agonist cycle, and associations between P/F ratios and fertility/pregnancy outcomes were analyzed. Results: Patients with a P/F ratio of 0.11 or above had higher serum progesterone levels (P<0.001) and lower serum estradiol levels (P<0.001) on the day of human chorionic gonadotropin administration in comparison with patients with lower P/F ratios; elevated P/F ratios were also associated with fewer follicles at least 14 mm in size (P<0.001) and lower live delivery rates (P<0.001). Multiple logistic regression confirmed that P/F ratio was an independent predictor of live delivery rate (P=0.001). Conclusion: A P/F ratio of at least 0.11 was associated with lower live delivery rates in women with normal ovarian reserve undergoing cleavage-stage embryo transfer with a long gonadotropin-releasing hormone agonist cycle.


王晓琴

Predictors of quality of life among Chinese people with schizophrenia

Nursing and Health Sciences. 2017, 19, 142-148(第一作者)

论文摘要:

This study was designed to investigate the association of quality of life, perceived stigma, and medication adherence among Chinese patients with schizophrenia, and to ascertain the predictors of quality of life. A cross-sectional correlation study was conducted with 146 participants. All participants completed self-report scales: the Schizophrenia Quality of Life Scale, Link's Stigma Scale, and the Morisky Medication Adherence Scale. Pearson parametric correlations and stepwise multiple regressions were performed. The total quality of life score and psychosocial subscale was significantly positively correlated with perceived stigma, coping orientation of withdrawal, and feelings of stigma, and negatively correlated with age and medication adherence. The means of all subscale scores except perceived devaluation-discrimination and different/guilty feelings were significantly higher than the midpoint of 2.5. The best predictors of quality of life and psychosocial domains were stigma-related feelings: feeling misunderstood, feeling different/shame, and age. Our findings suggest that an individual's negative emotional response may strengthen internalized stigma and decrease quality of life. As the best predictor, age indicated that adaptation to mental illness may relieve perceived stigma and achieve favorable quality of life.


向浩

论文摘要:

1. Association between ambient fine particulate matter and preterm birth or term low birth weight: An updated systematic review and meta-analysis

Environmental Pollution. 2017 Apr 27. pii: S0269-7491(16)32550-7. doi:10.1016(通讯作者)

An increasing number of studies have been conducted to determine a possible linkage between maternal exposure to ambient fine particulate matter and effects on the developing human fetus that can lead to adverse birth outcomes, but, the present results are not consistent. A total of 23 studies published before July 2016 were collected and analyzed and the mean value of reported exposure to fine particulate matter (PM2.5) ranged from 1.82 to 22.11 We found a significantly increased risk of preterm birth with interquartile range increase in PM2.5 exposure throughout pregnancy (odds ratio (OR) ? 1.03; 95% conditional independence (CI): 1.01e1.05). The pooled OR for the association between PM2.5 exposure, per interquartile range increment, and term low birth weight throughout pregnancy was 1.03 (95% CI: 1.02e1.03). The pooled ORs for the association between PM2.5 exposure per 10 increment, and term low birth weight and preterm birth were 1.05 (95% CI: 0.98e1.12) and 1.02 (95% CI: 0.93e1.12), respectively throughout pregnancy. There is a significant heterogeneity in most meta-analyses, except for pooled OR per interquartile range increase for term low birth weight throughout pregnancy. We here show that maternal exposure to fine particulate air pollution increases the risk of preterm birth and term low birth weight. However, the effect of exposure time needs to be further explored. In the future, prospective cohort studies and personal exposure measurements needs to be more widely utilized to better characterize the relationship between ambient fine particulate exposure and adverse birth outcomes.

 

2. The Short-term Effect of Air Pollutants on Respiratory Diseases Mortality in Wuhan, China: Comparison of Time Series and Case-crossover Analysis

Scientific Report 7:40482(通讯作者)

Few studies have compared different methods when exploring the short-term effects of air pollutants on respiratory disease mortality in Wuhan, China. This study assesses the association between air pollutants and respiratory disease mortality with both time-series and time-stratified–case-crossover designs. The generalized additive model (GAM) and the conditional logistic regression model were used to assess the short-term effects of air pollutants on respiratory disease mortality. Stratified analyses were performed by age, sex, and diseases. A 10 μg/m3 increment in SO2 level was associated with an increase in relative risk for all respiratory disease mortality of 2.4% and 1.9% in the case-crossover and time-series analyses in single pollutant models, respectively. Strong evidence of an association between NO2 and daily respiratory disease mortality among men or people older than 65 years was found in the case-crossover study. There was a positive association between air pollutants and respiratory disease mortality in Wuhan, China. Both time-series and case-crossover analyses consistently reveal the association between three air pollutants and respiratory disease mortality. The estimates of association between air pollution and respiratory disease mortality from the case–crossover analysis displayed greater variation than that from the time-series analysis.


3. Propensity to Migrate and Willingness to Pay Related to Air Pollution among Different Populations in Wuhan, China.

Aerosol and Air Quality Research. 2017, 17:752-760, doi: 10.4209/aaqr.2016.05.0178(通讯作者)

Few studies have compared different methods when exploring the short-term effects of air pollutants on respiratory disease mortality in Wuhan, China. This study assesses the association between air pollutants and respiratory disease mortality with both time-series and time-stratified–case-crossover designs. The generalized additive model (GAM) and the conditional logistic regression model were used to assess the short-term effects of air pollutants on respiratory disease mortality. Stratified analyses were performed by age, sex, and diseases. A 10 μg/m3 increment in SO2 level was associated with an increase in relative risk for all respiratory disease mortality of 2.4% and 1.9% in the case-crossover and time-series analyses in single pollutant models, respectively. Strong evidence of an association between NO2 and daily respiratory disease mortality among men or people older than 65 years was found in the case-crossover study. There was a positive association between air pollutants and respiratory disease mortality in Wuhan, China. Both time-series and case-crossover analyses consistently reveal the association between three air pollutants and respiratory disease mortality. The estimates of association between air pollution and respiratory disease mortality from the case–crossover analysis displayed greater variation than that from the time-series analysis.


杨冰香

论文摘要:

Incidence, Type, Related Factors, and Effect of Workplace Violence on Mental Health Nurses: A Cross-sectional Survey.

Archives of Psychiatric Nursing. doi:10.1016/j.apnu.2017.09.013. (In Press)(第一作者)

1. Abstract

OBJECTIVE: Workplace violence and its impact on mental health nurses have yet to be thoroughly explored in China. This study aims to investigate the incidence, type, related factors, and effects of workplace violence on mental health nurses as well as identifying coping strategies.

METHODS: A researcher - designed workplace violence questionnaire and the Maslach Burnout Inventory- General Survey were distributed to nurses at a mental health hospital in Wuhan, China.

RESULTS: Most nurses reported a high incidence of workplace violence (94.6%) in the past year ranging from verbal aggression, sexual harassment, to physical attack. The forms of violence significantly correlated with each other (r > 0.5, p=0.000). Working on the psychiatric intensive care unit for adult males and being a male nurse placed nurses at significantly higher risk for workplace violence. Providing routine treatment, caring for male patients, and working the night shift increased the risk of sexual harassment. Nurses who believed that workplace violence was preventable experienced a significantly lower incidence of violence. Burnout levels of the mental health nurses were relatively mild, but increased with age, professional title, years of employment and frequency of workplace violence.

CONCLUSION: The incidence of workplace violence among mental health nurses is common, and its frequency is correlated with nurses' level of burnout. Management and clinical nurses should work together on an organization-wide strategy targeting the major identified risk areas to reduce the incidence of workplace violenceand minimize its impact on nurses.

KEYWORDS:

Workplace violence, Aggression, Burnout, Mental health, Nurses, China

2. The effect of a community mental health training program for multidisciplinary staff.

Arch Psychiatr Nurs. doi:10.1016/j.apnu.2017.12.007 (In Press)(第一作者)

Abstract

Background: Primary health workers play a critical role in providing health education to people with mental disorders. In China community health workers working with people with mental health problems lack experience and training in this area. Additionally, coordination between hospital and community staff is not well established. The aim of this study was to provide an interdisciplinary community mental health training program and to evaluate the effect of the training on staff knowledge about mental health and confidence in their roles.

Methods: A three-day community mental health training program was offered specifically for interdisciplinary mental health professionals. Using a one-group pre-test post-test design, participants completed a self-assessment of mental health concepts and program evaluation which included asking participants to rate their satisfaction using a five-point Likert scale and to respond to open-ended questions.

Results: Forty-eight participants including health professionals from colleges, hospital and community health centers were recruited. Only 8.7% of participants had ever received community mental health training. Post-test evaluation demonstrated improvements in knowledge, and most participants were very satisfied with the program.

Conclusion: The findings indicate that this brief interdisciplinary training program had a positive effect in improving knowledge about community mental health concepts and confidence in dealing with people with mental health disorders for multidisciplinary staff working in primary health care areas.

Keywords:

Community health education, Interdisciplinary education, Training program, Mental health

3. Translation and Adaptation of a Nursing Swearing Impact Questionnaire Into Chinese.

J Am Psychiatr Nurses Assoc, doi:10.1177/1078390317725385. (In Press)(第三作者)

Abstract

BACKGROUND: Verbal aggression and swearing are the most frequently encountered violence in the health care industry. Nurses are the most frequent victims. Not known is the incidence and impact of swearing against nurses in China. OBJECTIVES: (a) Develop a Chinese version of the Nursing Swearing Impact Questionnaire; (b) report the preliminary findings from the use of the tool. METHOD: Using a translation–back translation procedure, focus groups and expert review, followed by a survey of 32 participants.

RESULTS: The Chinese version of the Nursing Swearing Impact Questionnaire has been developed, and cultural differences and different attitudes toward verbal aggression and swearing in disparate groups and workplaces have been highlighted. CONCLUSIONS: This is the first Chinese tool to research nurses’ perspectives and experiences of swearing in the workplace. Nurses in China face serious challenges, and the impact of swearing on nurses requires more attention.

Keywords

Chinese culture, Nursing Swearing Impact Questionnaire, swearing, cursing, verbal aggression


张军

论文摘要:

1 Perceptions of simulation-assisted teaching among baccalaureate nursing students in Chinese contexts: benefits, process and barriers

J Prof Nursing, 2017 Jul-Aug, 33(4): 305-310(第一作者)

AIM: To explore the subjective learning experiences of baccalaureate nursing

students participating in simulation sessions in a Chinese nursing school.

METHOD: This was a qualitative descriptive study. We used semi-structured

interviews to explore students' perception about simulation-assisted learning.

Each interview was audio-taped and transcribed verbatim. Thematic analysis was

used to identify the major themes or categories from the transcript and the field

notes.

FINDINGS: Only 10 students were needed to achieve theoretical saturation, due to

high group homogeneity. Three main themes which were found from the study

included 1. Students' positive views of the new educational experience of

simulation; 2. Factors currently making simulation less attractive to students;

and 3. The teacher's role in insuring a positive learning experience.

CONCLUSION: Simulation-assisted teaching has been a positive experience for

majority nursing students. Further efforts are needed in developing quality

simulation-based course curriculum as well as planning and structuring its

teaching process. The pedagogy approach requires close collaboration between

faculty and students.


2 Effects of a mixed media education intervention program on increasing knowledge, attitude, and compliance with standard precautions among nursing students: A randomized controlled trial

Am J Infect Control, 2017 Apr; 45 (4): 389-395(第二作者)

BACKGROUND: Standard precautions (SPs) are considered fundamental protective

measures to manage health care-associated infections and to reduce occupational

health hazards. This study intended to assess the effectiveness of a mixed media

education intervention to enhance nursing students' knowledge, attitude, and

compliance with SPs.

METHOD: A randomized controlled trial with 84 nursing students was conducted in a

teaching hospital in Hubei, China. The intervention group (n?=?42) attended 3

biweekly mixed media education sessions, consisting of lectures, videos,

role-play, and feedback with 15-20 minutes of individual online supervision and

feedback sessions following each class. The control group learned the same

material through self-directed readings. Pre- and posttest assessments of

knowledge, attitudes, and compliance were assessed with the Knowledge with

Standard Precautions Questionnaire, Attitude with Standard Precautions Scale, and

the Compliance with Standard Precautions Scale, respectively. The Standard

Bacterial Colony Index was used to assess handwashing effectiveness.

RESULTS: At 6-week follow-up, performance on the Knowledge with Standard

Precautions Questionnaire, Attitude with Standard Precautions Scale, and

Compliance with Standard Precautions Scale were significantly improved in the

intervention group compared with the control group (P?<?.01). The hand hygiene

standard in the intervention group (38 passed) outperformed the control group (23

passed) (P?<?.01).

CONCLUSIONS: A mixed media education intervention is effective in improving

knowledge, attitude, and compliance with SPs.

3 Validating the psychometric characteristics of the perinatal posttraumatic stress disorder questionnaire (PPQ) in a Chinese context

Archives of Psychiatric Nursing, 2017 (第二作者)

This is the first methodological study to validate the psychometric characteristics of the Perinatal Posttraumatic Stress Disorder Questionnaire (PPQ) among Chinese mothers. The results showed that the Chinese version of the PPQ is a reliable and valid measure of perinatal posttraumatic stress disorder (PPTSD) symptoms in a Chinese context. The Chinese version of PPQ (PPQ-C) provides a foundation for examining the psychometric characteristics and use of the PPQ with Chinese mothers in future research.


张志将

Risk of Death Is Higher After Stent Postdilation in Patients With Acute Coronary Syndrome.

Am J Cardiol. 2017 Aug 15;120(4):720-721. (第一作者)

论文摘要:

Karjalainen et al performed a post hoc analysis of the BASE ACS trial, a prospective randomized trial of titanium-nitride-oxide-coated bioactive stents versus everolimus-eluting stents in acute coronary syndrome (ACS). The primary end point was the first occurrence of major adverse cardiac events: a composite of cardiac death, nonfatal myocardial infarction (MI), or ischemia-driven target lesion revascularization. The secondary end points were noncardiac death and definite stent thrombosis. Their analysis showed that the rates of nonfatal MI were significantly lower among those

who underwent postdilation versus those who did not (4.5% vs 8.5%, p=0.02), while no significant differences were observed for other end points, including cardiac death, ischemia driven target lesion revascularization, noncardiac death, or definite stent thrombosis. And the rates of the composite end point, major adverse cardiac events, were similar at long-term follow-up among patients who underwent stent postdilation versus those who did not (15.7% vs 15.1%, p=0.81). Based on these findings, the investigators conclude that stent postdilation is useful in treating ACS. However, in our opinion, this is an uncritical acceptance of stent postdilation at face value without considering the increased risk of death.




马露

Spatiotemporal Changes in Fine Particulate Matter Pollution and the Associated Mortality Burden in China between 2015 and 2016

Int. J. Environ. Res. Public Health 2017, 14(11), 1321; doi:10.3390/ijerph14111321(通讯作者)

论文摘要:

In recent years, research on the spatiotemporal distribution and health effects of fine particulate matter (PM2.5) has been conducted in China. However, the limitations of different research scopes and methods have led to low comparability between regions regarding the mortality burden of PM2.5. A kriging model was used to simulate the distribution of PM2.5 in 2015 and 2016. Relative risk (RR) at a specified PM2.5 exposure concentration was estimated with an integrated exposure–response (IER) model for different causes of mortality: lung cancer (LC), ischaemic heart disease (IHD), cerebrovascular disease (stroke) and chronic obstructive pulmonary disease (COPD). The population attributable fraction (PAF) was adopted to estimate deaths attributed to PM2.5. 72.02% of cities experienced decreases in PM2.5 from 2015 to 2016. Due to the overall decrease in the PM2.5 concentration, the total number of deaths decreased by approximately 10,658 per million in 336 cities, including a decrease of 1400, 1836, 6312 and 1110 caused by LC, IHD, stroke and COPD, respectively. Our results suggest that the overall PM2.5 concentration and PM2.5-related deaths exhibited decreasing trends in China, although air quality in local areas has deteriorated. To improve air pollution control strategies, regional PM2.5 concentrations and trends should be fully considered.


燕虹

论文摘要:

1) The influence of condom use during the first-time anal intercourse on the subsequent sexual behaviors among young men who have sex with men in China

Biomedical Research 2017; 28 (19): 8537-8541(通讯作者)

HIV infection rate within Chinese Young Men who have Sex with Men (YMSM) dramatically increased in recent years, and the major cause is widespread unprotected sexual behavior without using condoms.This study explored the influence of condom use during the first-time anal intercourse on subsequent homosexual behaviors among YMSM in China. Multivariate logistic regression analysis was used to identify correlated factors with condom use at the first time; Odd Ratios (OR) with 95% Confidence Interval (CI) were calculated. Of 371 YMSM, 50.7% used a condom during the first-time anal intercourse. YMSM were more inclined to neglect of using a condom during the first-time anal intercourse if they were younger (OR=3.262, P=0.001) or their first-time sexual partners were schoolmates (OR=3.543, P<0.001). Compared to YMSM who used a condom at first time, YMSM who did not use a condom during the first-time anal intercourse were more likely to neglect of using condoms during subsequent oral sexes (OR=2.992, P<0.001), anal sexes (OR=3.144, P<0.001) and sexes after drinking alcohols (OR=5.331, P=0.005). Findings suggest that YMSM who did not use a condom during the first-time anal intercourse were more likely to produce unprotected sexual behavior subsequently.


2) Associations between sexual sensation seeking and AIDS-related knowledge, attitudes and behaviors among young men who have sex with men in China

Psychology, Health & Medicine, 2017,22(5):596-603(通讯作者)

Young men who have sex with men (YMSM) have become high risk groups for HIV infection in China. Recent researches suggest that sexual sensation seeking is significantly associated with AIDSrelated knowledge, attitudes and behaviors, but the relationship is not clear in the field of YMSM in China. The present study aimed to evaluate the relationship between sexual sensation seeking and AIDS-related knowledge, attitudes, and behaviors among YMSM in China. A cross-sectional study was conducted in Wuhan, China from May to November 2013. 403 YMSM were recruited and 373 of them completed the questionnaire. Regression analyses indicated that YMSM with high sexual sensation seeking score are more likely to have low awareness of knowledge and negative attitude about condom use, as well as more risky sexual behaviors.


李十月


论文摘要:

1Epidemiological characteristics and environmental risk factors of Severe Fever with Thrombocytopenia Syndrome in Hubei province, China, from 2011 to 2016

Frontiers in Microbiology, 2017, 8: e111736(通讯作者)

Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne viral disease affecting hundreds of people in China each year. To better understand the epidemiological characteristics and environmental risk factors associated with the incidence of SFTS in Hubei Province, China, we conducted a retrospective epidemiological study and risk assessment of SFTS from 2011 to 2016. Although, the incidence and epidemic areas of SFTS are increasing, the fatality rate has decreased. Elderly farmers are the population most commonly infected with SFTS virus between May and July in the northeast Hubei Province, which seems to be consistent with local agricultural activities and the seasonal abundance of ticks. Spatial scanning showed that regions bordering with Xinyang City, Henan Province accounted for most of the SFTS cases in Hubei Province, and there was a significant association of SFTS incidence with temporal changes in the climate within these clusters. Multivariate modeling analysis identified density of cattle, rain-fed cropland, built-up land, temperature, and relative humidity as independent risk factors for the distribution of SFTS. Future epidemiological and serological studies are warranted to elucidate the dynamics and immunity patterns of local SFTS disease and to optimize interventions.

2Psychological pathway to suicidal ideation among People Living with HIV/AIDS in China: A Structural Equation Model

Psychiatry Res. 2017, 260:255-261(通讯作者)

People living with HIV/AIDS (PLWHA) have higher rates of suicide than does the general population. It is critical to interpret the intricate relationships among various psychological variables that increase the risk of suicidal ideation among PLWHA in China. An institutional based cross-sectional study was conducted from Jul to Aug 2016 in Nanjing, China, using a self-reporting questionnaire. A total of 465 PLWHA participated. Sociodemographic, psychological variables and suicide information about the participants were collected. Structural equation modelling (SEM)-path analysis was used to analyze the cross-sectional data. The final structural equation model had a highly satisfactory fit. Among PLWHA, perceived stigma had the greatest accumulated total effect on suicidal ideation, with both a direct effect and indirect effect through self-esteem and depression. Additionally, self-esteem had the second greatest total effect on suicidal ideation and was influenced by social support. Depression contributed directly to suicidal ideation and partly mediated the association of perceived stigma and self-esteem with suicidal ideation. These findings suggest that self-esteem and depression, particularly perceived stigma, play important roles in suicidal ideation among PLWHA. Enhancing personal self-esteem or social support might also reduce perceived stigma and may be an important target for intervention to decrease suicidal ideation among PLWHA.

宇传华

论文摘要:


[1] Zhang Yunquan, Peng Minjin, Wang Lu, Yu Chuanhua*. Association of diurnal temperature range with daily mortality in England andWales: A nationwide time-series study. Science of the Total Environment, 2018, 619620:291300. SCI IF=4.90

Abstract

BACKGROUND:

Diurnal temperature range (DTR) reflects within-day temperature variability and is closely associated with climate change. In comparison to temperature extremes, up-to-date DTR-health evidence at the regional and national scales has been still very limited worldwide, especially in Europe.

OBJECTIVES:

This study aimed to provide nationwide estimates for DTR-associated effects on mortality, and explore whether season and regional-level characteristics modify DTR-mortality relation in United Kingdom.

METHODS:

Fourteen-year time-series data on weather and mortality were collected from 10 regions in England and Wales during 1993-2006, including 7,573,716 total deaths. A quasi-Poisson regression incorporated with distributed lag non-linear model was first applied to estimate region-specific DTR-mortality relationships. Then, a multivariate meta-analysis was employed to derive the pooled DTR effects at the national level. Also, the modifying effects of some regional characteristics (e.g., geographical and climatological) were examined by conducting multivariate meta-regression.

RESULTS:

A non-linear DTR-mortality relationship was identified in UK. At the national level, increasing DTR raised the mortality risk observably when DTR exposure was below 25th percentile or above 90th percentile of DTR distribution, with an intermediate risk plateau indicating no associations. Extremely high DTR exhibited greater adverse effect estimates in hot season compared with in cold and transitional season, whereas entirely different association patterns were observed for the season-specific effects of extremely low DTR. In addition to season, regional latitudes, average temperature and humidity were also found to significantly modify DTR-mortality relationship.

CONCLUSIONS:

Our study added strong evidence that extremely high DTR increased short-term mortality, whereas the effects of extremely low DTR exhibited entirely different seasonal patterns. Also, mortality vulnerability to DTR extremes varied greatly by regional latitudes and climate conditions.


[2] Yuan Ruixia, Wu Hairong, Zeng Heng, Liu Ping, Xu Quangang, Gao Lu, Li Yin, Li Rendong, Huang Duan, Yu Chuanhua*, Sun Xiangdong**. Prevalence of and risk factors for cystic echinococcosis among herding families in five provinces in western China: a cross-sectional study. Oncotarget, 2017, 8(53): 91568-91576. (SCI IF= 5.168)

Abstract

Echinococcosis is a severe zoonosis that endangers the health of herdsmen in China's western provinces. This study aimed to examine the prevalence of this disease and identify potential factors associated with human echinococcosis among herding families. A cross-sectional study was conducted in five provinces in western China from May 1, 2016 to November 30, 2016, and 1500 herding families participated in the study. A total of 1211 completed questionnaires were analyzed. The prevalence of Cystic echinococcosis (CE) among surveyed herding families was 1.55%. The results of multivariate analysis revealed that the sheep immunization (OR=0.35, 95%CI 0.21-0.58), being concerned about family members echinococcosis (OR=0.49, 95%CI 0.28-0.84) were protective factors, while allowing dogs to roam free (OR=3.17, 95%CI 1.89-5.31), feeding dogs with viscera (OR=3.04, 95%CI 1.83, 5.03), slaughter at home (OR=3.53, 95%CI 2.04-6.12), drinking non-boiled water (OR=2.15, 95%CI 1.28-3.63), eating raw vegetables (OR=1.87, 95%CI 1.13-3.10), not washing hands before meals (OR=3.08, 95%CI 1.68-5.65), and often seeing stray dogs (OR=2.60 95%CI 1.38-4.91) and wild animals (OR=1.92, 95%CI 1.17-3.14) near habitations were more associated with increased risk of infection. Immunizing sheep, appropriately managing domestic and stray dogs, and improving living environments and behavioral factors may help to reduce the risk of human echinococcosis in western China.

KEYWORDS:

Chinas western provinces; cystic echinococcosis; herding families; prevalence; risk factors


[3] Zhang Yunquan, Yu Chuanhua*, Peng Minjin, Zhang Lan. The burden of ambient temperature on years of life lost: A multi-community analysis in Hubei, China. Science of The Total Environment, 2017, Available online 18 October 2017. https://doi.org/10.1016/j.scitotenv.2017.10.079   SCI IF=4.90

Abstract

BACKGROUND:

Compared with death rates, years of life lost (YLL) has been widely used as a more informative indicator to quantify the burden of premature death. In the context of global climate change, existing evidence linking ambient temperatures and YLL was very scarce across the globe.

METHODS:

Daily mortality and meteorological data during 2009-2012 were obtained from 12 communities across Hubei Province in central China. A two-stage approach was used for statistical analysis. At the first stage, a generalized linear regression combined with distributed lag non-linear model was applied to estimate community-specific temperature-YLL associations. A second-stage multivariable meta-analysis was then conducted to pool the community-specific estimates of temperature-related effects on YLL.

RESULTS:

A pooled J- or U-shaped association was observed between ambient temperature and YLL due to different mortality categories. Heat effects occurred immediately and only persisted for several days, whereas cold effects were delayed and much longer-lasting. At the provincial level, heat effect (per 1°C increase from 75th to 99th percentile of temperature) at lag 0-2days and cold effect (per 1°C decrease from 25th to 1st percentile of temperature) at lag 0-21days was associated with an increase of 1.91% (95% CI: 0.83, 3.00) and 5.09% (2.79, 7.40) in YLL due to non-accidental deaths, respectively. Much greater effect estimates of cold than heat were also observed for other mortality-specific YLLs (except for respiratory mortality). Heat effects on YLL were higher for males and the youth, while cold effects were greater for females and the elderly. Additionally, relatively stronger associations between heat, cold and YLL were consistently observed in low-educated persons.

CONCLUSIONS:

This multi-community study strengthened the evidence that both cold and hot temperatures were associated with increased years of life lost. Our findings may have important implications for better understanding the burden of premature death related to temperature extremes.

Copyright © 2017 Elsevier B.V. All rights reserved.


[4] Zhang Yunquan, Peng Minjin, Yu Chuanhua*, Zhang Lan. Burden of mortality and years of life lost due to ambient PM10 pollution in Wuhan, China. Environmental Pollution, 2017, 230:1073-1080. DOI: 10.1016/j.envpol.2017.07.053 SCI IF=5.0989

Abstract

Ambient particulate matter (PM) has been mainly linked with mortality and morbidity when assessing PM-associated health effects. Up-to-date epidemiologic evidence is very sparse regarding the relation between PM and years of life lost (YLL). The present study aimed to estimate the burden of YLL and mortality due to ambient PM pollution. Individual records of all registered deaths and daily data on PM10 and meteorology during 2009-2012 were obtained in Wuhan, central China. Using a time-series study design, we applied generalized additive model to assess the short-term association of 10-μg/m3 increase in PM10 with daily YLL and mortality, adjusting for long-term trend and seasonality, mean temperature, relative humidity, public holiday, and day of the week. A linear-no-threshold dose-response association was observed between daily ambient PM10 and mortality outcomes. PM10 pollution along lag 0-1 days was found to be mostly strongly associated with mortality and YLL. The effects of PM10 on cause-specific mortality and YLL showed generally similar seasonal patterns, with stronger associations consistently occurring in winter and/or autumn. Compared with males and younger persons, females and the elderly suffered more significantly from both increased YLL and mortality due to ambient PM10 pollution. Stratified analyses by education level (0-6 and 7 + years) demonstrated great mortality impact on both subgroups, whereas only low-educated persons were strongly affected by PM10-associated burden of YLL. Our study confirmed that short-term PM10 exposure was linearly associated with significant increases in both mortality incidence and years of life lost. Given the non-threshold adverse effects on mortality burden, the on-going efforts to reduce particulate air pollution would substantially benefit public health in China.

KEYWORDS:

Air pollution; China; Mortality; Particulate matter; Years of life lost



[5] Zhang Yunquan, Yu Chuanhua*, Yang Jin, Zhang Lan, Cui Fangfang. Diurnal Temperature Range in Relation to Daily Mortality and Years of Life Lost in Wuhan, China. Int. J. Environ. Res. Public Health, 2017, 14(8):891. http://www.mdpi.com/1660-4601/14/8/891/  (SCI IF=2.101  SCI + SSCI)

Abstract

Diurnal temperature range (DTR) is an important meteorological indicator associated with global climate change, and has been linked with mortality and morbidity in previous studies. To date, however, little evidence has been available regarding the association of DTR with years of life lost (YLL). This study aimed to evaluate the DTR-related burden on both YLL and mortality. We collected individual records of all registered deaths and daily meteorological data in Wuhan, central China, between 2009 and 2012. For the whole population, every 1 °C increase in DTR at a lag of 0-1 days was associated with an increase of 0.65% (95% CI: 0.08-1.23) and 1.42 years (-0.88-3.72) for mortality and YLL due to non-accidental deaths, respectively. Relatively stronger DTR-mortality/YLL associations were found for cardiovascular deaths. Subgroup analyses (stratified by gender, age, and education level) showed that females, the elderly (75+ years old), and those with higher education attainment (7+ years) suffered more significantly from both increased YLL and mortality due to large DTR. Our study added additional evidence that short-term exposure to large DTR was associated with increased burden of premature death using both mortality incidence and YLL.

KEYWORDS:

China; climate change; diurnal temperature range; mortality; years of life lost


[6] Luo Lisha, Jiang Junfeng, Zhang Ganshen, Wang Lu, Wang Zhenkun, Yang Jin, Yu Chuanhua*. Stroke Mortality Attributable to Ambient Particulate Matter Pollution from 1990 to 2015 in China: An Age-Period-Cohort and Spatial Autocorrelation Analysis. Int. J. Environ. Res. Public Health, 2017, 14(7):772. http://www.mdpi.com/1660-4601/14/7/772 (SCI IF=2.101  SCI + SSCI)

Abstract

In this study, we analyzed the temporal and spatial variations of stroke mortality attributable to ambient particulate matter pollution (stroke mortality-PM2.5) in China from 1990 to 2015. Data were collected from the Global Burden of Disease (GBD) 2015 study and analyzed by an age-period-cohort model (APC) with an intrinsic estimator (IE) algorithm, as well as spatial autocorrelation based on the Geographic Information System. Based on APC analysis with the IE method, stroke mortality-PM2.5 increased exponentially with age, its relative risk reaching 42.85 (95% CI: 28.79, 63.43) in the 75-79 age group. The period effects showed a reversed V-shape and its highest relative risk was 1.22 (95% CI: 1.15, 1.27) in 2005. The cohort effects decreased monotonically from 1915-1919 to 1990-1994. The change rate fluctuated from 1920-1924 to 1990-1994, including three accelerating and three decelerating decreases. There was a positive spatial autocorrelation in stroke mortality-PM2.5 from 1990 to 2015. Hot-spots moved from the northeastern areas to the middle and southwestern areas, whereas cold-spots lay mostly in coastal provinces. Besides the aging process in recent years, stroke mortality-PM2.5 had significantly declined from 2005 to 2015 due to socio-economic and healthcare development. Stroke mortality-PM2.5 varied substantially among different regions, and cost-effective prevention and control should be implemented more in the middle and southwestern areas of China.

KEYWORDS:

PM2.5; age-period-cohort analysis; mortality; spatial autocorrelation; stroke


[7] Zhang Yunquan, Yu Chuanhua*, Wang Lu. Temperature exposure during pregnancy and birth outcomes: An updated systematic review of epidemiological evidence, Environmental Pollution, 2017, 225: 700-712.  (SCI IF=5.099 SCI + SSCI)

Abstract

Seasonal patterns of birth outcomes have been observed worldwide, and there was increasing evidence that ambient temperature played as a trigger of adverse birth outcomes, such as preterm birth (PTB), low birth weight (LBW), and stillbirth. To systematically review updated epidemiological evidence about the relationship between temperature exposure during pregnancy and PTB, LBW, and stillbirth, we searched for related studies published in English from electronic databases and references of identified papers. We only included original articles that directly reported the effects of prenatal temperature exposure on birth outcomes. The characteristics and main findings of included studies were examined. A total of 36 epidemiological studies were finally included in this review. Most of these studies focused on PTB and LBW, while less attention has been paid to stillbirth that was relatively rare in the occurrence. Several designs including ecological (e.g., descriptive and time-series) and retrospective cohort studies (e.g., case-crossover and time-to-event) were applied to assess temperature effects on birth outcomes. Temperature metrics and exposure windows varied greatly in these investigations. Exposure to high temperature was generally found to be associated with PTB, LBW, and stillbirth, while several studies also reported the adverse impact of low temperature on birth outcomes of PTB and LBW. Despite no conclusive causality demonstrated, the current evidence for adverse effect on birth outcomes was stronger for heat than for cold. In summary, the evidence linking birth outcomes with ambient temperature was still very limited. Consequently, more related studies are needed worldwide and should be conducted in diversified climate zones, so as to further ascertain the association between temperature and birth outcomes. Future studies should focus on more sophisticated study designs, more accurate estimation of temperature exposure during pregnancy, and more efficient methods to find out the exposure windows, as well as cold-related effects on birth outcomes.

KEYWORDS:

Low birth weight; Pregnancy; Preterm birth; Review; Stillbirth; Temperature



[8] Zhang Yunquan, Yu Chuanhua*, Bao Junzhe, Li Xudong. Impact of temperature on mortality in Hubei, China: a multi-county time series analysis. Scientific Reports2017, 7:45093. http://dx.doi.org/10.1038/srep45093. (SCI IF=4.259)

Abstract

We examined the impact of extreme temperatures on mortality in 12 counties across Hubei Province, central China, during 2009-2012. Quasi-Poisson generalized linear regression combined with distributed lag non-linear model was first applied to estimate county-specific relationship between temperature and mortality. A multivariable meta-analysis was then used to pool the estimates of county-specific mortality effects of extreme cold temperature (1st percentile) and hot temperature (99th percentile). An inverse J-shaped relationship was observed between temperature and mortality at the provincial level. Heat effect occurred immediately and persisted for 2-3 days, whereas cold effect was 1-2 days delayed and much longer lasting. Higher mortality risks were observed among females, the elderly aged over 75 years, persons dying outside the hospital and those with high education attainment, especially for cold effects. Our data revealed some slight differences in heat- and cold- related mortality effects on urban and rural residents. These findings may have important implications for developing locally-based preventive and intervention strategies to reduce temperature-related mortality, especially for those susceptible subpopulations. Also, urbanization should be considered as a potential influence factor when evaluating temperature-mortality association in future researches.



[9] Zhang Yunquan, Yu Chuanhua*, Bao Junzhe, Li Xudong. Impact of temperature variation on mortality: An observational study from 12 counties across Hubei Province in China. Sci Total Environ, 2017, 587:196-203. (SCI IF=4.900)

Abstract

BACKGROUND:

Compared with cold- and heat-related health impacts, the evidence was very limited in assessing the mortality effects of temperature variation (TV) accounting for both intra-day and inter-day changes in temperature.

OBJECTIVE:

We used a newly proposed composite indicator of intra-day and inter-day TV and evaluated TV-mortality associations in Hubei, China at the provincial level.

METHODS:

Daily mortality and meteorological data during 2009-2012 were obtained from 12 urban and rural counties across Hubei Province in China. TV was calculated using the standard deviation of the minimum and maximum temperatures during the exposure days. A quasi-Poisson generalized linear regression combined with distributed lag non-linear model was first applied to estimate county-specific relationship between mortality and TV, adjusting for long-term trend and seasonality, mean temperature, relative humidity, public holiday, and day of the week. A meta-analysis was then conducted to pool the county-specific estimates of TV-related mortality effects.

RESULTS:

A significant positive association was observed between TV and cause-specific mortality (except for respiratory mortality and ischemic heart disease mortality). The effect estimates varied by exposure days, with the highest at 0-7days. Season-stratified analyses showed similar results, while stronger TV-mortality associations were found in warm season than in cold season. The elderly were more susceptible to TV-related mortality effects than younger groups. Some slight differences in effect estimates were also observed in subgroups stratified by gender, education attainment, place of death, and urban/rural areas.

CONCLUSION:

Our study strengthened the evidence that temperature variation was an independent risk factor for non-accidental mortality. Some preventive and intervention strategies should be efficiently developed in response to global climate change, so as to minimize public health burden due to unstable weather patterns.

Copyright © 2017 Elsevier B.V. All rights reserved.

KEYWORDS:

China; Climate change; Diurnal temperature range; Mortality; Temperature variation



[10] Wang Zhenkun, Hu Songbo, Sang Shuping, Luo Lisha, Yu Chuanhua *. AgePeriodCohort Analysis of Stroke Mortality in China Data From the Global Burden of Disease Study 2013. Stroke, 2017, 48(2):271-275.被《医师报》选为2016十大流行病学研究)(SCI IF=6.032

Abstract

BACKGROUND AND PURPOSE:

Stroke has been the leading cause of death in China. The aim of this study is to assess the long-term trends of stroke mortality in China between 1994 and 2013.

METHODS:

The mortality data were obtained from the GBD 2013 (Global Burden of Disease Study 2013) and were analyzed with the age-period-cohort framework.

RESULTS:

We found that the net drift was -2.665% (95% confidence interval, -2.854% to -2.474%) per year for men and -4.064% (95% confidence interval, -4.279% to -3.849%) per year for women, and the local drift values were below 0 in all age groups (P<0.05 for all) in both sexes during the period of 1994 to 2013. In the same birth cohort, the risk of death from stroke rose exponentially with age for both sexes after controlling for period deviations. The estimated period and cohort relative risks were found in similar monotonic downward patterns (significantly with P<0.05 for all) for both sexes, with more quickly decreasing for women than for men during the whole period (significantly with P<0.05 for both).

CONCLUSIONS:

The decreased mortality rates of stroke in China are likely to be related to improvements in medical care and techniques, spectacular economic growth and fast urbanization, and better early life nutrition conditions of Chinese people. Besides, better education and better awareness of stroke-related knowledge in successive generations could also probably play a role.

© 2016 American Heart Association, Inc.

KEYWORDS:

China; cause of death; mortality rate; risk; stroke; trends



[11] Global Burden of Disease Liver Cancer Collaboration, Akinyemiju T, Abera S, ..., Yu C, Zaidi Z, Zhu L, Murray CJL, Naghavi M, Fitzmaurice C. The Burden of Primary Liver Cancer and Underlying Etiologies From 1990 to 2015 at the Global, Regional, and National Level: Results From the Global Burden of Disease Study 2015. JAMA Oncol, 2017, 2017 Oct 5. doi: 10.1001/jamaoncol.2017.3055.  (SCI IF= 15.559)

[12] GBD 2015 Neurological Disorders Collaborator Group(Feigin Valery L, Abajobir Amanuel Alemu, K Abate alkidan Hassen, , Yu Chuanhua, Zaidi Zoubida, Zaki Maysaa El Sayed, Zunt Joseph R, Murray Christopher J L, Vos Theo). Global, regional, and national burden of neurological disorders during 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Neurol, 2017, 16(11):877-897.  (SCI IF= 26.284) http://dx.doi.org/10.1016/S1474-4422(17)30299-5

[13] GBD 2016 DALYs and HALE Collaborators(Hay Simon I, Alemu Abajobir Amanuel, Abate Kalkidan Hassen, Yu Chuanhua,, [...]Murray Christopher J L). Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 19902016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet, 2017, 390(10100): 1260-1344. (SCI IF=47.831 SCI + SSCI)

[14] Pandian Jeyaraj Durai, William Akanksha G , Kissela Brett M, Yu Chuanhua, Feigin Valery L. Strategies to Improve Stroke Care Services in Low- and Middle-Income Countries: A Systematic Review. Neuroepidemiology, 2017, 49:4561. SCI IF= 2.8859

[15] GBD 2015 Chronic Respiratory Disease Collaborators (Soriano Joan B, Abajobir Amanuel Alemu, Yu Chuanhua,, et al. Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 19902015: a systematic analysis for the Global Burden of Disease Study 2015. The Lancet Respiratory Medicine, 2017, 5(9): 691-706. SCI IF= 19.287

[16] GBD 2015 Eastern Mediterranean Region Adolescent Health Collaborators (Azzopardi P, Yu Chuanhua, , Mokdad AH, et al). Adolescent health in the Eastern Mediterranean Region: findings from the global burden of disease 2015 study. Int J Public Health, 2017, Aug 3. doi: 10.1007/s00038-017-1003-4. SCI IF=2.3269

[17] GBD 2015 Eastern Mediterranean Region Maternal Mortality Collaborators Khalil I, Yu Chuanhua, , Mokdad AH, et al). Maternal mortality and morbidity burden in the Eastern Mediterranean Region: findings from the Global Burden of Disease 2015 study. Int J Public Health, 2017, Aug 3. doi: 10.1007/s00038-017-1004-3. SCI IF=2.3269

[18] GBD 2015 Eastern Mediterranean Region Mental Health Collaborators (Charara RE, Bcheraoui C, , Yu C,, Mokdad AH, et al). The burden of mental disorders in the Eastern Mediterranean region, 1990-2015: findings from the global burden of disease 2015 study. Int J Public Health, 2017, Aug 3. doi: 10.1007/s00038-017-1006-1. SCI IF=2.3269

[19] GBD 2015 Eastern Mediterranean Region Cardiovascular Disease Collaborators (Tehrani-Banihashemi A,, Yu Chuanhua, , Mokdad AH, et al). Burden of cardiovascular diseases in the Eastern Mediterranean Region, 1990-2015: findings from the Global Burden of Disease 2015 study. Int J Public Health, 2017, Aug 3. doi: 10.1007/s00038-017-1012-3.

[20] GBD 2015 Eastern Mediterranean Region Neonatal, Infant, and under-5 Mortality Collaborators (Khalil I,, Yu Chuanhua, , Murray CJL., et al). Neonatal, infant, and under-5 mortality and morbidity burden in the Eastern Mediterranean region: findings from the Global Burden of Disease 2015 study. Int J Public Health, 2017, Aug 3. doi: 10.1007/s00038-017-0998-x.

[21] GBD 2015 Healthcare Access and Quality Collaborators (Barber Ryan M, Fullman Nancy, Sorensen Reed J D, , Yu Chuanhua, Zaidi Zoubida, , Murray Christopher J L*). Healthcare Access and Quality Index based on mortality from causes amenable to personal health care in 195 countries and territories, 19902015: a novel analysis from the Global Burden of Disease Study 2015. Lancet, 2017, 390(10091): 231-266. (SCI IF=47.831 SCI + SSCI)

[22] Roth Gregory A, Johnson Catherine, Abajobir Amanuel, , Yu Chuanhua, Vos Theo, Naghavi Mohsen, Murray Christopher. Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015. Journal of the American College of Cardiology, 201770(1):1-25.  http://dx.doi.org/10.1016/j.jacc.2017.04.052   (SCI IF=19.896)

[23] Global Burden of Disease Health Financing Collaborator Network (Dieleman JL, Campbell M, Chapin A, , Yu C, Zaidi Z, El Sayed Zaki M, Murray CJL.). Future and potential spending on health 2015-40: development assistance for health, and government, prepaid private, and out-of-pocket health spending in 184 countries. Lancet, 2017, 389(10083): 2005-2030. (SCI IF=47.831 SCI + SSCI)

[24] Global Burden of Disease Health Financing Collaborator Network(Dieleman J, Campbell M, Chapin A, , Yu C, Zaidi Z, El Sayed Zaki M, Murray CJL.). Evolution and patterns of global health financing 1995-2014: development assistance for health, and government, prepaid private, and out-of-pocket health spending in 184 countries. Lancet, 2017, 389(10083): 1981-2004.  (SCI IF=47.831 SCI + SSCI)

[25] GBD 2015 Tobacco Collaborators (Reitsma MB, Fullman N, Ng Marie, ,yu Chuanhua,, Murray CJL, Forouzanfar MH, Gakidou E). Smoking prevalence and attributable disease burden in 195 countries and territories, 19902015: a systematic analysis from the Global Burden of Disease Study 2015. Lancet, 2017, 389(10082): 1885-1906.  (SCI IF=47.831 SCI + SSCI)

[26] The Global Burden of Disease Child and Adolescent Health Collaboration (Kassebaum Nicholas, Kyu Hmwe Hmwe, Zoeckler Leo, , Younis Mustafa Z., Yu Chuanhua, , Murray Christopher J. L., Vos Theo). Child and Adolescent Health From 1990 to 2015 Findings From the Global Burden of Diseases, Injuries, and Risk Factors 2015 Study. JAMA Pediatr, 2017, 171(6):573-592. (SCI IF=10.251 SCI + SSCI)

[27] Global Burden of Disease Cancer Collaboration (Fitzmaurice Christina, Allen Christine, Barber Ryan M.,Yu Chuanhua, Zaidi Zoubida, Murray Christopher JL, Naghavi Mohsen). Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015: A Systematic Analysis for the Global Burden of Disease Study.  JAMA Oncology, 2017, 3(4):524-548.SCI IF=16.559热点论文11

[28] Wei Min, Liu Yu*, Wang Chunhong, Yu Chuanhua, Li Dejia, Zhou Wei, Zhang Zhi-Jiang. The need for differentiating diabetes-specific mortality from total mortality when comparing metformin with insulin regarding cancer survival. Acta Diabetol, 2017, 54(2): 219-220.   SCI IF=3.34